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KMID : 0390119930330020311
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Journal of Pusan Medical College
1993 Volume.33 No. 2 p.311 ~ p.316
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Serum Levels of Soluble CD8 in Hemodialyzed Patients with Chronic Renal Failure
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Abstract
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In an attempt to evluate the usefulness of serum soluble CD8(sCD8) levels as parameters of cellular immunodysfunction in hemodialyzed patients with chronic renal diseases, the author investigated serum levels of sCD8 by sandwich enzyme
immunoassay
in 44
cases of hemodialyzed patients with chronic renal failure and 27 cases of adult healthy subjects as control.
In these patients the mean serum creatinine and SUN levels just before dialysis were 13.0±4.0 mg/dl(5.0~21.0mg/dl) ad 91.0±28.0 mg/dl(36.0~147mg/dl), respectively. The duration of hemodialysis ranged from 6 months to 96 months(average 35
months).
The blood samples were obtained from patients just before dialysis and adult health subjects in Pusan National University Hospital and some Hospitals of Pusan area during the period of January to August, 1993.
@ES The results obtained were summarized as follows:
@EN 1. Serum Levels of sCD8 were significantly in hemodialized patients as compared with bealthy controls, and were increased with duration of hemodialysis.
2. The percentage of CD8+ cells was not different hemodialyzed patients and healthy subjects.
3. No significant correlation was noted between serum CD8 levels and percentage/absolute counts of peripheral CD8+ cells in healthy control subjects and hemodialyzed patients.
On the basis of the above results, ti an suggested that serum levels of sCD8 reflect partially the status of immune activation and can be useful as a parameter of immune dysfuction in hemodialzyed patients with chronic renal failure.
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KEYWORD
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